People with CF produce abnormally thick and sticky mucus that can damage body organs. The mucus interrupts the function of vital organs, especially the lungs, and leads to chronic infections.
CF also involves the pancreas and causes decreased absorption of essential nutrients and can cause reproductive system damage. With improved treatment and management of the disease, affected people may live well into adulthood. Ultimately, death most often occurs from respiratory failure.
Other people with variants of CF may have only lung involvement, sinusitis, or infertility. Sickle cell anemia is another common, inherited, single-gene disorder found mostly in African Americans.
About 1 in African-American babies is born with sickle cell anemia. About 1 in 12 African Americans carries the gene for this disease. Sickle cell disease involves the hemoglobin in the red blood cells and their ability to carry oxygen. Normal red blood cells are smooth, round, and flexible, like the letter "O.
Sickle cells are stiff and sticky. Note: These outcomes do not mean that the children will definitely be carriers or be severely affected.
Clinical genomics. Textbook of Family Medicine. Philadelphia, PA: Elsevier Saunders; chap Human genetics and patterns of inheritance.
Philadelphia, PA: Elsevier; chap 1. Korf BR. Principles of genetics. Our Housecall e-newsletter will keep you up-to-date on the latest health information. Mayo Clinic does not endorse companies or products.
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The concept of reduced penetrance is particularly important in the case of autosomal dominant cancer susceptibility genes. If a person has inherited a cancer susceptibility gene, it does not mean they will automatically develop cancer. It simply means that the person has inherited a mutation in a gene that gives them a higher chance to develop cancer than someone without the mutation.
Search Encyclopedia. Autosomal Dominant Inheritance Genes are the blueprints for making proteins.
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